Laser Imager for Lab Animals (LILA)

• Optical Computed Tomography of Fluorescent Tags in Small Laboratory Animals
• LILA Model M510: Images green fluorescent protein (GFP) in nude mice. Other fluorphores and lab animals to follow.
• An optical helical CT scanner in a third-generation configuration, with a 488nm CW laser fluorescence excitation source.
• LILA images GFP, an intrinsic fluorophore, derived from jellyfish.
• Immunodeficient Model M510: Images green fluorescent protein (GFP) in nude mice. Other fluorophores and lab animals to follow nude mice host tumors transfected with GFP-expressing DNA.
• LILA visualizes GFP-expressing tumors for accurate serial quantification.
• LILA acquires optical attenuation and GFP fluorescence data simultaneously
• A collaborative development with the Rumbaugh-Goodwin Institute for Cancer Research, Inc. (Plantation, FL)
• Not for human or veterinary use. Patent pending. Work-in-progress.

• Third-generation geometry, helical scanning optical CT scanner
• Source laser: 25 milliWatts CW at 488nm
• Beam size: < 1.0mm (1/e2)
• Detector: 84 photodiodes, 42 filtered for fluorescence, interdigitated
• Scan volume: 45mm diameter x 140mm maximum length
• Enclosure: Light-tight, well ventilated
• Dimensions: 600mm x 400mm x 400mm (W x H x D)
• Weight: 40kg including scanner
• User's Terminal: Pentium 4 PC, 19" LCD display, Windows 2000
• Electrical: 100-250VAC, 47-63Hz, 400W maximum. Uninterruptable power supply standard

• 3-D optical computed tomography. Volumetrically accurate.
• Molecular imaging of green fluorescent protein, an intrinsic fluorophore - no injectibles required
• Presents optical attenuation and fluorescence volume images of anatomic and physiologic data
• Multiplanar reconstruction and interactive 3-D display of volume data
• Quantification of signal intensity, distance, area and volume
• Display of multiple volumes for serial comparisons

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